3-Mercaptopropionic acid-mediated synthesis of peptide and protein thioesters† †Electronic supplementary information (ESI) available: Experimental procedures for the production of 1, all model peptides and proteins and their reactions with MPA including HPLC, LC-MS and NMR characterisation of selected products. See DOI: 10.1039/b815888f Click here for additional data file.

摘要

Peptides and proteins fragment in the presence of 3-mercaptopropionic acid to afford thioesters which can be used in native chemical ligation reactions.